2019 Journal > JOURNAL CLUB | 정밀의학 유전체 연구실

2019 Journal

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2019

Date	Presenter	Title	Journal
01 / 04	YU Lee	Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma	Cell Death Dis.
01 / 11	MJ Cho	A conserved enhancer regulates Il9 expression in multiple lineages	Nat. Commun.
01 / 18	JW Lee	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress	Nat. Commun.
01 / 25	DW Kim	Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming	Nat. Commun.
02 / 08	EJ Choi	A map of constrained coding regions in the human genome	Nature Genet.
02 / 15	Khanh Chu	Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas	Nat. Commun.
03 / 04	JH Hwang	Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis	Cancer Cell
03 / 28	JY Lee	Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements	Nature Genet.
04 / 19	HR Shim	Identification of differentially methylated cell types in epigenome-wide association studies	Nat. Methods
04 / 19	HR Shim	Bulk tissue cell type deconvolution with multi-subject single-cell expression reference	Nat. Commun.
04 / 26	HR Shim	Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen	Nat. Commun.
05 / 03	HR Shim	KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer	Cancer Cell
05 / 10	HR Shim	Somatic mutations increase hepatic clonal fitness and regeneration in chronic liver disease	Cell
05 / 17	SC Kim	Genomic and transcriptomic landscape of triple-negative breast cancers: subtypes and treatment strategies	Cancer Cell
05 / 24	SC Kim	Whole genome sequencing put forward hypotheses on metastasis evolution and therapy in colorectal cancer	Nat. Commun.
06 / 21	JM Kim	A biparatopic HER2-targeting antibody-drug conjugate induces tumor regression in in primary models refractory to or ineligible for HER2-targeted therapy	Cancer Cell
06 / 28	JI Jun	Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties	Cancer Cell
07 / 05	YT Kim	Quantitative evidence for early metastatic seeding in colorectal cancer	Nature Genet.
07 / 12	JY Lee	PI3Ka-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease	Nat. Commun.
07 / 19	MJ Cho	Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions	Immunity
07 / 26	YU Lee	Antisense lncRNA transcription mediates DNA demethylation to drive stochastic protocadherin a promoter choice	Cell
08 / 02	JH Hwang	Developmental dynamics of lncRNAs across mammalian organs and species	Nature
08 / 16	JY Lee	Characterizing the major structural variant alleles of the human genome	Cell
08 / 30	MH Jung	Integrative transcriptome imputation reveals tissue-speciﬁc and shared biological mechanisms mediating susceptibility to complex traits	Nat. Commun.
09 / 20	HR Shim	Accurate detection of m6A RNA modifications in native RNA sequences	Nat. Commun.
09 / 27	YT Kim	Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells	Nature Genet.
10 / 18	HJ Kim	Synaptic proximity enables NMDAR signaling to promote brain metastasis	Nature
10 / 25	JM Kim	Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophage	Proc. Natl. Acad. Sci.
11 / 01	JM Kim	Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL- 1R protein SARM	Immunity
11 / 08	JI Jun	Whole-genome sequencing reveals novel tendem-duplication hotspots and a prognostic mutational signature in gastric cancer	Nat. Commun.
11 / 15	SC Kim	Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients	Nat. Commun.
11 / 22	JY Lee	Protein Kinase D at the Golgi controls NLRP3 inflammasome activation	J. Exp. Med.
11 / 29	YU Lee	Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers	Nat. Commun.
12 / 05	MJ Cho	Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis	Nature
12 / 13	EJ Choi	Functional enhancers shape extrachromosomal oncogene amplifications	Cell

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